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Physics 1E03 Version 1 Test March 22, 2010 Test Duration: 80 min Instructors: G. Luke (section C01) N. McKay (sections C02 and C03) W. Okon (sections C04, C05 and C06) Name_________________________________ Student Number:________________________ Mac email:__________________@mcmaster.ca Instructor:______________________________ Write your name and student number on your paper before you begin. Multiple-choice questions are worth 2 marks each, and problems are worth 3 marks each. Only the McMaster standard calculator is allowed. Notes and formula sheets are not permitted. A sheet of formulae is attached as the last page. Answers for the multiple-choice questions (Part A) must be marked on the optical scan sheet, using an HB pencil. Before you begin, print your name on this paper and on the optical scan sheet. Code your student number in the spaces provided on the scan sheet as well. You must code your student number correctly, and correctly answer the first question (which asks for your test version) to receive full marks. Problems (Part B) are to be answered directly on this test paper in the spaces provided. Clear and complete solutions are required for full marks. PLEASE DO NOT WRITE IN THIS AREA Part A (18) 11 (3) 12 (3) 13 (3) 14 (3) Part B (12) See ELM Page 2 of 7 Part A : Indicate the best or most nearly correct answer by filling in the corresponding circle on the optical scan sheet with an HB pencil. Each correct answer is worth 2 marks. An incorrect answer or unanswered question counts as zero marks. 1) Your test is version 1. Fill in the circle “A” or “1” on your scan sheet as the answer to Question 1. Now proceed to question 2 2) When the current in a particular wire is doubled, A) the resistivity is reduced by half B) the electric field in the wire doubles C) the electron number density doubles D) all of the above 3) The net outwards magnetic flux through any closed surface is equal to A) zero. B) the total outward current through the surface times μ 0 . C) the emf induced in the enclosed volume. D) the surface charge density divided by ε 0 . 4) A long straight wire carries a current I in it. At a distance R from the centerline of the wire the magnitude of the magnetic field is B. What is the magnetic field at distance 5R from the centerline of the wire? A) 5B B) 25B C) B/25 D) B/5 5) When a current is sent through the straight in the direction indicated by the arrow in the diagram, which direction will the wire move in? A) To the left ← B) To the right → C) Out of the page D) Into the page E) It will not be deflected 6) Given the circuit segment in the diagram with the current flowing in the direction indicated, what is the potential difference between the points a and b, V a - V b , equal to? A) - ε + IR B) - ε - IR C) ε + IR D) ε - IR ε I R a b I

CS | 102 | Machine Learning | Physics 1E03 Version 1 Test Ma

Which of the following graphs would explain why ethanol is an effective treatment for methanol poisoning. 13. You want to choose something that is a competitive inhibitor so you want the Km to increase and Vmax to stay constant i. Graph A a. Substrate concentrations a. All enzymes are regulated by 14. Activate or deactivate an enzyme a. Introduce a negative charge and a covalent bond b. Phosphorylation of an enzyme will 15. If you have an increase in Km- most likely competitive inhibition i. The amino acid substitution likely occurs in the active site and affects electrostatic interactions a. Remember high Km means concentrations of acid aldehyde build up and you get drunk quicker i. Individuals with the genetic variant in ALDH@ do not metabolize alcohol very well b. What can u conclude from the data? 16. Doubling [S] will not affect the K m or V max 17. Remember that salts can act as an uncompetitive inhibitor which affects both a. 1 M NaCl will change both Km and Vmax 18. Mixed noncompetitive inhibitor affect both Km and Vmax 19. Competitive inhibitor will affect Km 20. Noncompetitive inhibitor will affect Vmax 21. The reaction for hydrolysis has a high activation energy a. The hydrolysis of ATP has a large negative delta G, however, the molecule is quite stable in solution. How can this be explained? 22. The first step in the metabolism of glucose involved the addition of a phosphate group catalyzed by the enzymes hexokinase/glucokinase 23. The following applies to enzymes that show M-M kinetics Biochem Page 2 -16.7 kJ/mol a. Favorable reactions release energy a. Favorable reactions increase entropy b. Favorable reactions have a negative delta G c. Which of the following determines whether a reaction is favorable? 24. Measure of energy available to do work a. Depends on the concentrations of reactants and products b. Depends on the change in bond energy between reactants and products c. Delta G is dependent on Entropy d. The following question refers to delta G. 25. They lower the activation energy of a reaction a. Which of the following statements applies to enzyme catalysts? 26. The turnover number (kcat) a. The number of substrate converted to product per mole of enzyme in a given unit of time is defined as: 27. Low Km is usually advantageious i. Aspargine-1 a. Which of the following variants of asparagine in the table below would be the most effective? 28. Enzymes are facinating macromolecules that may be required for certain reactions in the cell to proceed. They can speed up or slow down a reaction by changing its Activation Energy . Their action can also be regulated by inhibitors or activators. In competitive inhibition the inhibitor will bind to the Active Site of the enzyme, thereby modifying its ability to function properly. Pharmaceutical companies may take advantage of the fact that the Transition state always bind very tightly to the enzyme and therefore design inhibitors of the enzyme to mimic this structure. 29. Remember that delta G is not dependent on reaction rate. Enzymes affect reaction rate i. -5.6 a. 30. The transition state is stabilized by the enzyme but the bonds are strained a. A molecule that mimics the transition state binds to the enzyme more tightly b. A molecule that resembles the transition state may be an effective competitive inhibitor c. The higher the free energy difference between the substrate and the transition state, the slower the reaction d. The following statements refer to the transition state 31. Stabilization of transition state a. What is the common strategy by which catalysis occurs? 32. Doubling the enzyme concentration affects the V max 33. Uncompetitive inhibitor decreases both Km and Vmax 34. Biochem Page 3

CS | 102 | Machine Learning | Which of the following graphs 

Answers to Quiz 3 ECON 3M03 Spring 09 1. A market has two firms, firm L and firm H. They both simultaneously choose quantities of output ( and L q H q respectively). Their output is pooled and sold to competitive buyers at the market clearing price: ( ) 30 L H P q q = − + . Firm L's total cost of production is 3 and firm H's total cost of production is higher at 6 . The firms' payoffs are their profits (revenue minus costs). What are the firms' best responses? What is the Nash equilibrium? L q L q ( ) ( ) ( ) ( ) ( ) { } ( ) ( ) { } ( ) 2 27 1 2 2 27 1 2 2 2 1 2 1 2 27 1 2 2 27 15 1 1 1 2 2 2 2 4 1 2 3 30 3 27 27 2 0 max 0, 24 24 2 0 12 max 0,12 12 12 10 L L L H L H L L H L L H L L H H H L H H H L H H L H H L L L H L L H L L H u P q q q q q q q u q q q q q BR q q u q q q u q q q q q BR q q q q q q q q q q q = − = − + − = − − ∂ = − − = ⇒ = − ∂ = − = − − ∂ = − − = ⇒ = − ∂ = − = − ⎫ ⇒ = − − = + ⎬ = − ⎭ = L L ( ) 1 1 2 2 12 12 10 7 L q = − = − = So the Nash equilibrium is ( ) ( ) , 7,1 H L q q = 0 2. One evening there are 10 people living in an apartment building who can all hear a crime being committed outside. They must each independently decide whether or not to call the police. Each person gets a payoff of zero if no one calls the police, a payoff of x (where 1 x > ) if someone else calls the police, and a payoff of 1 x − if they call the police themselves. Interpreting x as a measure of the severity of the crime (so that larger x means a more serious crime and thus people are happier if it is stopped) are more serious crimes more likely to result in someone calling the police (at the symmetric mixed- strategy Nash equilibrium)? [ ] [ ] [ ] [ [ ] ( ) [ ] 1 Call, Don't Call, 1 Pr Someone Else Calls 0 Pr No One Else Calls 1 1 Pr No One Else Calls Pr No One Else Calls i i i i u s u s x x x x x − − − = − = + − = − = ] Defining p as the probability a given individual doesn't call at the Nash equilibrium: 9 1 1 9 p x p x − − = = Defining P as the probability that someone calls at the Nash equilibrium: 10 10 9 19 9 1 1 10 0 9 P p x P x x − − = − = − ∂ = > ∂ So as the severity of the crime increases (i.e. as x increases) the probability that someone calls increases.

CS | 102 | Machine Learning | Answers to Quiz 3 ECON 3M03 Sp

CS | 102 | Machine Learning | 

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