Genetics

Cell Biology

Section Problems I For discussion during week 10, BICD 100 Winter 2013 1) A large, randomly mating population is started by individuals with the following proportions of blood types: 0.5 MM 0.2 MN 0.3 NN This blood type gene is autosomal and the M and N alleles are codominant. a) Is the initial population at Hardy-Weinberg equilibrium? No (be sure that you know how you could test this using chi-square analysis if needed) b) What will be the allele and genotype frequencies after one generation of mating under the conditions assumed by the Hardy-Weinberg principle? allele frequencies: for M, 0.6; for N, 0.4 genotype frequencies: 0.36 MM; 0.48 MN; 0.16 NN c) What will be the allele and genotype frequencies after two generations of mating under the conditions assumed by the Hardy-Weinberg principle? same as in part b 2) A phenotypically normal couple has had one normal child and one child with cystic ﬁbrosis, an autosomal recessive disease. The incidence of cystic ﬁbrosis in the population from which this couple came is 1/625. If their normal child eventually marries a phenotypically normal person from the same population, what is the likelihood that this couple will produce a child with cystic ﬁbrosis? 2/3 x 48/625 x 1/4 = 8/625

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