Discussion 2  Simple-Sequence Repeats o Can cause problems with Backward Slippage  Crossing Over can also cause issues (elongation or shortening)  PCR can be used to detect repeats (by amplifying) o 1) Denature o 2) Anneal primer o 3) Elongation 

Lecture_06.docx-Lecture 06  P-Value o P-Value

Questions from slides since quiz 7 (and a few extra): *I’ll post answers later in the week Lecture 13 How do we expect removal of the stuffer fragment to affect the transformation results? What is the genetic content of a white colony? Do we expect t

Lecture_04.docx-Lecture 04  Multiple Steps of

Lecture 05  Scoring o P R ( A,B ) = P A ∗ P B is easy to compute (simply use residue frequencies) o We’d like to be able to align truly orthologous sequences to compute P O ( A,B ) o Chicken and egg problem  To compute alignments, we need a score f