Anatomy and Physiology Lab I

Clinical Immunology

Microbiology

Dr.Fagan Clinical Immunology Extra Credit Exam Questions 1. All of the following are antibody class types except: a. IgA b. IgG c. Ig F d. IgM e. Ig E 2. What is the normal life span of a naïve lymphocyte? a. 5-7 days b. 1-3 months c. 1-2 hours d. 3-7 weeks e. 4-10 hours 3. How many constant regions does one IgM heavy chain have? a.1 b.2 c.3 d.4 e.5 4. What cytokine is required or isotope switching to IgG? a. IL-4 b. IL-2 c. TGF-beat d. IFN-gamma 5. At what T cell stage would you expect it to be in the infected tissue? a. Pre-T cell b. Immature T cell c. Mature naïve T cell d. Active T cell

BIOL | 3703 | Clinical Immunology | exam | Dr.Fagan Clinical Immunology E

Preimmunizaon sera from each rabbit failed to immunoprecipitate any albumin preparaon. a. Discuss the reacvity of each serum with its appropriate SA. The reacvity of serum with its appropriate serum albumin is strong hence, relavely higher amount of Immunoprecipitate is formed due to high speciﬁcity between angen and anbody. b. Discuss the rea

Discussion_5.docx.docx-Preimmunizaon sera from each rabbit failed

Microbiology_Unit_1_Quiz.docx-Microbiology Unit 1 Study Guide (1-5)

3703, Disc 10 A woman was seen in a rheumatology clinic with stiff painful joints in her hands which were worse first thing in the morning. Other symptoms included fatigue, a low-grade fever, weight loss, and a nonspecific rash on her face and chest. She had elevated serum IgG levels, was positive for anti-nuclear antibodies, and low complement levels. A ren

3703_Discussion_10.docx.docx-Disc 10 A woman was seen

3703, Discussion question 8 Two months before admission, a 26 year old Caucasian man developed progressive fever, weight loss, tiredness, a non-productive cough, vague chest pain, sore throat, and diarrhea. His TB skin test had been positive years earlier and he had been vaccinated with the MMR vaccine. On examination, he was a thin, pale, chronically ill appearing man. Routine laboratory studies revealed anemia, and a moderate decrease in total lymphocytes. Assessment of his immune system indicated normal immunoglobulin and nonspecific inflammatory responses (complement and phagocyte function). His cellular immune functions were severely impaired. Skin tests with PPD (TB skin test) and mumps antigens were negative. No significant in vitro proliferation could be detected to mitogen or antigens including PPD and mumps. 1. Do you think this is a genetic or acquired immunodeficiency? Why?  acquired-->usually inherited defects would occur at birth. He is no longer responding to Ag that he responded to in the past (PPD/TB, MMR/mumps) 2. What additional information about this patient’s history would you want to have in order to explain how this individual became immunodeficient?  share needles (abusing drugs), medications (steroids), sexual history, infections, transfusions travel or located of residence, environmental exposure 3. What infectious organism could produce this form of immune dysfunction?  human immunodeficiency virus (HIV) 4. What tests could you do to confirm what infectious agent was causing this disease?  Elisa (Ab to HIV), western blot 5. What opportunistic organisms should be considered as a possible cause of his pulmonary complaints?  PCP (pneumocystic carinii pneumonia), mycobacterium avian 6. Would you expect this patient to be unusually susceptible to neoplasms (cancer)? If so, why?  -neoplasm=tumor/cancer  -yes, poor Tc function See Parham pg 375, 386-391, 395-396.

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