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Posaconazole.docx
Posaconazole.docx
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Posaconazole.docx-Class Brand Name Generic Name Me...
Posaconazole.docx-Class Brand Name Generic Name Mechanism
Posaconazole.docx-Class Brand Name ...
Posaconazole.docx-Class Brand Name Generic Name Mechanism
Page 1
Class
Brand
Name
Generic
Name
Mechanism of
Acon
Indicaon
Inial,
maintenance,
and max
dosages
Common adverse effects
Systemic
Azole
(Anfungal)
Noxafil
Posaconazole
Inhibits fungal
cell membrane
funcon by
interfering with
fungal
cytochrome
P450.
Oropharyngeal
candidiasis
Inial: 100mg
bid x1d
Maintenance:
100mg daily
x13d
HTN, hypotension, peripheral edema,
tachycardia, QT prolongaon, headache,
rigors, fague, insomnia, chills, dizziness,
rash/pruritus, hypokalemia, diarrhea,
nausea, voming, anorexia, abdominal pain,
thrombocytopenia, anemia, increased ALT,
musculoskeletal pain/weakness, cough,
epistaxis, pharyngis, fever
**All side effects listed have >10% incidence
**Drug interacons with sirolimus, HMG-
CoA Reductase Inhibitors, phenytoin,
digoxin, atazanavir, midazolam, drugs
prolonging QT interval
Lexicomp Online®, Lexi-Drugs®, Hudson, Ohio: Lexi-Comp, Inc.; March 19, 2018.
Woo, T. M., & Robinson, M. V. (2016).
Pharmacotherapeucs for advance pracce nurse prescribers.
Philadelphia: F.A. Davis
Company.
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